198419-90-8

198419-90-8 structure

Name: (±)-LY367385
Chemical Name: 4-[Amino(carboxy)methyl]-3-methylbenzoic acid
CAS Number: 198419-90-8
Molecular Formula: C₁₀H₁₁NO₄
Molecular Weight: 209.19900
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-08-30 19:43:14
Modify Date: 2024-01-23 19:50:49
(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].

Name	4-[Amino(carboxy)methyl]-3-methylbenzoic acid

Description	(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vivo	mGluR1a拮抗剂
References	[1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780. [2]. V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. europharmacology. 1999 Feb;38(2):199-207.