170984-72-2

170984-72-2 structure

Name: EGLU
Chemical Name: (2S)-2-amino-2-ethylpentanedioic acid
CAS Number: 170984-72-2
Molecular Formula: C₇H₁₃NO₄
Molecular Weight: 175.18200
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-01-29 12:06:54
Modify Date: 2024-01-04 11:18:33
EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent[1].

Name	(2S)-2-amino-2-ethylpentanedioic acid
Synonyms	EGLU Tocris-0971 L-Glutamic acid,2-ethyl

Description	EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vitro	EGLU (200 μM) selectively antagonizes (lS,3S)-ACPD-induced depressions of the monosynaptic component of the DRVRP, displaying little or no antagonist activity versus L-AP6 induced depressions or on the DRVRP alone[1].
References	[1]. Jane DE, et al. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.Neuropharmacology. 1996;35(8):1029-35.