184025-18-1
184025-18-1 structure
- Name: Ciproxifan
- Chemical Name: cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
- CAS Number: 184025-18-1
- Molecular Formula: C16H18N2O2
- Molecular Weight: 270.326
- Catalog: Biochemical Inhibitor Neuronal Signaling Histamine Receptor Antagonist
- Create Date: 2018-11-22 16:27:07
- Modify Date: 2024-01-11 13:52:49
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Ciproxifan(FUB-359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: 9.2 nM(Ki)Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
| Name | cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone |
|---|---|
| Synonyms |
Ciproxifan
cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl ketone Methanone, cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]- Cyclopropylpyrrol4-[3-(1H-imidazol-4-yl)propoxy] phenylmorphomethanone Cyclopropyl{4-[3-(1H-imidazol-4-yl)propoxy]phenyl}methanone FUB-359 cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone |
| Description | Ciproxifan(FUB-359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: 9.2 nM(Ki)Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 526.9±35.0 °C at 760 mmHg |
| Molecular Formula | C16H18N2O2 |
| Molecular Weight | 270.326 |
| Flash Point | 272.5±25.9 °C |
| Exact Mass | 270.136841 |
| PSA | 54.98000 |
| LogP | 2.29 |
| Appearance | solid | white |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.613 |
| Storage condition | -20℃ |
| Water Solubility | H2O: insoluble |
| Hazard Codes | Xn |
|---|---|
| Risk Phrases | 22-36/37/38-43 |
| Safety Phrases | 26-36/37/39 |
| WGK Germany | 3 |
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184025-18-1 |
| Literature: Archiv der Pharmazie, , vol. 333, # 9 p. 315 - 316 |
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184025-18-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3987 - 3994 |
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184025-18-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 43, # 21 p. 3987 - 3994 |
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184025-18-1 |
| Literature: Archiv der Pharmazie, , vol. 333, # 9 p. 315 - 316 |
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184025-18-1 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 20 p. 2379 - 2382 |
| Precursor 4 | |
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| DownStream 0 | |