64211-45-6
64211-45-6 structure
- Name: Oxiconazole
- Chemical Name: oxiconazole
- CAS Number: 64211-45-6
- Molecular Formula: C18H13Cl4N3O
- Molecular Weight: 429.127
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2018-07-03 12:10:19
- Modify Date: 2024-01-02 08:22:33
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Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3].
| Name | oxiconazole |
|---|---|
| Synonyms |
oxyconazole
Oxiconazolum [INN-Latin] (Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-[(2,4-dichlorophenyl)methyl]oxime, (1Z)- Oxiconazole [INN:BAN] Oxiconazolum Oxiconazol (1Z)-N-[(2,4-Dichlorobenzyl)oxy]-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanimine MFCD00865580 Oxiconazole Oxiconazol [INN-Spanish] Oxiconazole (INN) 2',4'-Dichlor-O-(2,4-dichlorbenzyl)-2-(1-imidazolyl)-(Z)-acetophenonoxim UNII-C668Q9I33J 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-(2,4-dichlorobenzyl) oxime |
| Description | Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CYP3A4 |
| In Vitro | Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3]. Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1]. Antifungal Activities of Oxiconazole[1]. Candida albicans Candida glabrata Candida parapsilosis Aspergillus fumigatus Aspergillus flavus Trichophyton mentagrophytes Trichophyton rubrum Oxiconazole 0.03 μg/mL 0.01 μg/mL 0.008 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL Cell Proliferation Assay[3] Cell Line: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 Concentration: 0-40 μM Incubation Time: 24 h Result: Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM. |
| In Vivo | Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3]. Animal Model: BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)[3] Dosage: 50 mg/kg/day Administration: IP; for 12 days Result: Significantly restrained CRC cell growth and showed no obvious side effects. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.8±60.0 °C at 760 mmHg |
| Molecular Formula | C18H13Cl4N3O |
| Molecular Weight | 429.127 |
| Flash Point | 302.6±32.9 °C |
| Exact Mass | 426.981262 |
| PSA | 39.41000 |
| LogP | 5.83 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.635 |
| HS Code | 2933290090 |
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| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |