334887-43-3

334887-43-3 structure

Name: HexylHIBO
Chemical Name: 2-amino-3-(4-hexyl-3-oxo-1,2-oxazol-5-yl)propanoic acid
CAS Number: 334887-43-3
Molecular Formula: C₁₂H₂₀N₂O₄
Molecular Weight: 256.29800
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2016-11-27 21:27:34
Modify Date: 2024-01-08 17:45:20
HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat[1].

Name	2-amino-3-(4-hexyl-3-oxo-1,2-oxazol-5-yl)propanoic acid
Synonyms	hexylhibo

Description	HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vitro	Thus ambient levels of glutamate tonically activate mGluRs and regulate cortical excitability[1].
References	[1]. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059. [2]. Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316.