Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HQNO
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: HQNO
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

341-88-8

341-88-8 structure

341-88-8 structure

Name: HQNO
Chemical Name: 2-heptyl-4-hydroxyquinoline N-oxide
CAS Number: 341-88-8
Molecular Formula: C₁₆H₂₁NO₂
Molecular Weight: 259.343
Catalog: Research Areas Infection
Create Date: 2018-12-02 21:42:51
Modify Date: 2024-01-03 12:01:30
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

Name	2-heptyl-4-hydroxyquinoline N-oxide
Synonyms	HOQNO 2-Heptylquinolin-4-ol 1-oxide 2 heptyl 4 hydroxyquinoline 1 oxide 4-Quinolinol,2-heptyl-,1-oxide 2-heptyl-1-hydroxyquinolin-4-one 2-Heptyl-4-quinolinol 1-oxide HQNO 4-Quinolinol, 2-heptyl-, 1-oxide 2-heptyl-4-hydroxyquinoline n-oxide

Description	HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
Related Catalog	Research Areas >> Infection
Target	NDH-2[2]
In Vitro	HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus. HQNO targets the Q-site of NDH-2[2]. HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E C. thermarum NDH-2 variant, respectively to determine IC50 values. WT NDH-2 has an IC50 value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC50 value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC50 value of 54.3±1.2 μM[2].
References	[1]. N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459(1):141-4. [2]. Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490.

Density	1.1±0.1 g/cm3
Boiling Point	445.8±37.0 °C at 760 mmHg
Melting Point	156-157ºC
Molecular Formula	C₁₆H₂₁NO₂
Molecular Weight	259.343
Flash Point	223.4±26.5 °C
Exact Mass	259.157227
PSA	42.23000
LogP	3.18
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.558

Hazard Codes	Xi
RTECS	VC5890000
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%