Name | N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride |
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Synonyms |
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-Acetoxy-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-6-yl N,N-dimethyl-β-alaninate hydrochloride (1:1)
colforsindapropatehydrochloride Adehl β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1) NKH 477 colforsin daropate hydrochloride 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl MKH 477 |
Description | NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. |
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Related Catalog | |
Target |
Adenylate Cyclase[1] |
In Vivo | NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1]. Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1] Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; daily; Days 3 and 5 Result: Prolonged lung allograft survival in a dose dependent manner. |
References |
Boiling Point | 571.4ºC at 760mmHg |
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Molecular Formula | C27H44ClNO8 |
Molecular Weight | 546.093 |
Flash Point | 176ºC |
Exact Mass | 545.275574 |
PSA | 122.60000 |
LogP | 2.82450 |
Vapour Pressure | 5.29E-16mmHg at 25°C |
Storage condition | 2-8°C |
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300 |
Precautionary Statements | P264-P301 + P310 |
Hazard Codes | T |
Safety Phrases | 28-36/37-45 |
RIDADR | UN 2811 6.1 / PGII |
RTECS | AY5992600 |