425-51-4

425-51-4 structure
425-51-4 structure

Name [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Synonyms 6,7-Dehydro-17Alpha-acetoxy Progesterone
17-Hydroxypregna-4,6-diene-3,20-dione acetate
6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione
Melengestro acetate
17-acetoxy-pregna-4,6-diene-3,20-dione
Megestil
Density 1.16g/cm3
Boiling Point 504.7ºC at 760mmHg
Molecular Formula C23H30O4
Molecular Weight 370.48200
Flash Point 218.7ºC
Exact Mass 370.21400
PSA 60.44000
LogP 4.18520

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4067000
CHEMICAL NAME :
Pregna-4,6-diene-3,20-dione, 17-hydroxy-, acetate (ester)
CAS REGISTRY NUMBER :
425-51-4
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H30-O4
MOLECULAR WEIGHT :
370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
25 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - other measures of fertility
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,3,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

~99%

425-51-4 structure

425-51-4

Literature: Boehringer Ingelheim International GmbH Patent: EP1359154 A1, 2003 ; Location in patent: Page/Page column title page; 4; 17; 25; 30; 32 ;

~%

425-51-4 structure

425-51-4

Literature: Yasuda,K. Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 1167 - 1174
Precursor  2

DownStream  0