93674-99-8

93674-99-8 structure

Name: H-Arg-Gly-Asp-Val-OH
Chemical Name: (2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
CAS Number: 93674-99-8
Molecular Formula: C₁₇H₃₁N₇O₇
Molecular Weight: 445.47100
Catalog: Research Areas Cancer
Create Date: 2018-12-29 11:45:09
Modify Date: 2024-01-01 22:58:24
RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect[1][2].

Name	(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
Synonyms	Rgdv tetrapeptide Arg-gly-asp-val Arginyl-glycyl-aspartyl-valine L-Arginylglycyl-L-alpha-Aspartyl-L-Valine

Description	RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	RGDV (25-100 nM; thrombus vessel model) selectively inhibits platelet-dependent thrombus formation and decreases the accumulation of both platelets and fibrin on the collagen substrate in a dose-response manner[1].
References	[1]. Cadroy Y, et, al. RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model. J Clin Invest. 1989 Sep;84(3):939-44. [2]. Wang F, et, al. Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif. J Pharm Sci. 2012 Dec;101(12):4559-68.