104206-65-7

104206-65-7 structure

Name: Nitisinone
Chemical Name: nitisinone
CAS Number: 104206-65-7
Molecular Formula: C₁₄H₁₀F₃NO₅
Molecular Weight: 329.228
Catalog: Research Areas Metabolic Disease
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-02 17:35:44
Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2].

Name	nitisinone
Synonyms	nitisinonum 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione 2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione Orfadin Nitisinone [INN] nitisinona Orfadin (TN) 1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]- Nitisone 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione Nitisinone

Description	Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Target: 4-Hydroxyphenylpyruvate DioxygenaseNitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Suwannarat, P., et al., Use of nitisinone in patients with alkaptonuria. Metabolism, 2005. 54(6): p. 719-28. [2]. Santra, S. and U. Baumann, Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother, 2008. 9(7): p. 1229-36.

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Blood - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 141,439,1996

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2914700090

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%