17851-53-5

17851-53-5 structure

Name: Butyl isobutyl phthalate
Chemical Name: 1-O-butyl 2-O-(2-methylpropyl) benzene-1,2-dicarboxylate
CAS Number: 17851-53-5
Molecular Formula: C₁₆H₂₂O₄
Molecular Weight: 278.344
Catalog: Research Areas Metabolic Disease
Create Date: 2016-04-28 19:42:17
Modify Date: 2024-01-03 06:24:57
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].

Name	1-O-butyl 2-O-(2-methylpropyl) benzene-1,2-dicarboxylate
Synonyms	Butyl isobutyl phthalate Phthalic acid,butyl isobutyl ester butyl 2-methylpropyl benzene-1,2-dicarboxylate phtalic acid n-butyl-iso-butyl ester EINECS 241-802-2 1,2-Benzenedicarboxylic acid, butyl 2-methylpropyl ester butyl-2-methylpropyl phthalate Phthalic acid, butyl isobutyl ester 1,2-benzenedicarboxylic acid,butyl 2-methylpropyl ester

Description	Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	IC50: 38 μM (α-glucosidase)[1]
In Vitro	Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC50 value of 38 μM[1].
In Vivo	Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively[1]. Animal Model: Streptozocin induced diabetic mice (Male Kunming mice)[1] Dosage: 25, 50 or 100 mg/kg Administration: Intragastric administration Result: Had the observed antidiabetes activity in mice.
References	[1]. Bu T, et al.α-Glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid.Phytother Res. 2010 Nov;24(11):1588-91.

HS Code	2917349000

HS Code	2917349000
Summary	2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%