24677-86-9

24677-86-9 structure

Name: Lenperone Hydrochloride
Chemical Name: Lenperone hydrochloride
CAS Number: 24677-86-9
Molecular Formula: C₂₂H₂₄ClF₂NO₂
Molecular Weight: 407.88100
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-30 12:14:22
Modify Date: 2024-01-11 13:57:01
Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].

Name	Lenperone hydrochloride
Synonyms	ahr-2277

Description	Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	Lenperone hydrochloride (0.16 和 0.44 mg/kg；肌内注射；一次) 降低健康犬的平均值胃食管括约肌压力 (GESP)[1]。 Lenperone hydrochloride (0.5，1.0 和 2.0 mg/kg；皮下注射) 在脑损伤大鼠中显示抗精神疾病的作用，诱导剂量依赖的镇静状态并减少双侧间质核、终纹[2]。 Animal Model: Healthy adult dogs[1] Dosage: 0.16 and 0.44 mg/kg Administration: Intramuscular injection; 0.16 and 0.44 mg/kg, once Result: Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs.
References	[1]. Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. [2]. Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58.

CHEMICAL NAME :: Butyrophenone, 4-(4-(p-fluorobenzoyl)piperidino)-4'-fluoro-, hydrochloride

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1,1970