101831-36-1

101831-36-1 structure

Name: Clazuril
Chemical Name: 2-[2-chloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-2-(4-chlorophenyl)acetonitrile
CAS Number: 101831-36-1
Molecular Formula: C₁₇H₁₀Cl₂N₄O₂
Molecular Weight: 373.19300
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-07-02 17:51:37
Modify Date: 2024-01-10 19:35:32
Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle[1].

Name	2-[2-chloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-2-(4-chlorophenyl)acetonitrile
Synonyms	CLAZURIL Clazurilum [Latin] [2-chloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl](4-chlorophenyl)acetonitrile Clazurilo [Spanish] Clazuril (USAN/INN) Clazurilo Clazurilum

Description	Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle[1].
Related Catalog	Research Areas >> Infection
In Vivo	Clazuril (2.5 mg/pigeon) results in a rapid suppression of oocyst excretion, but oocysts are again observed in the feces 20 days after treatment. The fact that oocysts appears again in the feces 3 to 5 weeks after treatment can probably be explained only by a persistence of endogenous stages, which are not affected during treatment, rather than by a reinfection [2].
References	[1]. W Coussement, et al. Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons. Res Vet Sci. 1988 Jul;45(1):117-9. [2]. J Vercruysse, et al. Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. Jan-Mar 1990;34(1):73-9.

103337-60-6

~11%

101831-36-1

Literature: Janssen Pharmaceutica N.V. Patent: US4631278 A1, 1986 ;