CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GL1224000
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CHEMICAL NAME :
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Conjugated estrogenic hormones
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CAS REGISTRY NUMBER :
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12126-59-9
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LAST UPDATED :
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199510
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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108 mg/kg/4Y-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors
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REFERENCE :
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AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 137,357,1977
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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27 mg/kg/3Y-C
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Liver - tumors
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REFERENCE :
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NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 78,1933,1978 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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3 mg/kg
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SEX/DURATION :
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female 1-5 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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REFERENCE :
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JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,1336,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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4167 ug/kg
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SEX/DURATION :
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female 1-5 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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REFERENCE :
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AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 115,101,1973 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,283,1987
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