94875-80-6
94875-80-6 structure
- Name: CI 75300
- Chemical Name: 1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
- CAS Number: 94875-80-6
- Molecular Formula: C22H22O5
- Molecular Weight: 366.40700
- Create Date: 2017-05-07 20:00:51
- Modify Date: 2024-01-14 10:23:19
| Name | 1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
|---|---|
| Synonyms |
diferuloyl methane
1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione 1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl) Curcumin,Curcuma longa L. |
| Density | 1.198g/cm3 |
|---|---|
| Boiling Point | 567.355ºC at 760 mmHg |
| Molecular Formula | C22H22O5 |
| Molecular Weight | 366.40700 |
| Flash Point | 197.595ºC |
| Exact Mass | 366.14700 |
| PSA | 72.83000 |
| LogP | 3.97270 |
| Index of Refraction | 1.617 |
|
Section I.Chemical Product and Company Identification Chemical Name Curcumin (Synthetic) Portland OR Synonym1,6-Heptadiene-3,5-dione, 1,7-bis (4-hydroxy-3-methoxyphenyl)- (CA INDEX NAME) Chemical FormulaC21H20O6
CAS Number94875-80-6 Section II.Composition and Information on Ingredients CAS Number Percent (%)TLV/PELToxicology Data Chemical Name Curcumin (Synthetic)Min. 98.0 (T) Not available.Rat LD50 (oral) 12.2gm/kg 94875-80-6 Mouse LD50 (oral) >2000mg/kg Mouse LD50 (ipr) 1500mg/kg Section III. Hazards Identification Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the Acute Health Effects eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Chronic Health EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS: Rat TDLo: Oral; 12600 mg/kg/6W continuous TOXIC EFFECTS: Tumorigenic - Neoplastic by RTECS criteria Liver - Tumors Tumorigenic - Facilitates action of known carcinogens DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS: Rat TDLo: Oral; 43 gm/kg; male 70D and70D prior to mating-1D after birth prior to mating. TOXIC EFFECTS: Effects on Newborn - Live birth index (similar to T26, except measured after birth) Effects on Newborn - Growth statistics (e.g., reduced weight gain) Rat TDLo: Oral; 10000 ppm; female multigeneration TOXIC EFFECTS: Effects on Newborn - Growth statistics (e.g., reduced weight gain) Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Section IV.First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or Inhalation waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Ingestion Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Continued on Next Page Curcumin (Synthetic) Section V.Fire and Explosion Data Not available. FlammabilityMay be combustible at high temperature.Auto-Ignition Flammable LimitsNot available. Flash PointsNot available. Combustion ProductsThese products are toxic carbon oxides (CO, CO2). Fire Hazards Not available. Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Section VI.Accidental Release Measures Irritating material. Possible tumorigenic material. Spill Cleanup In case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and excercise caution. Use a Instructions shovel to put material into a convenient waste disposal container. Consult federal, state and/or local authorities for assistance on disposal. Section VII. Handling and Storage Handling and StorageIRRITANT. POSSIBLE TUMORIGEN. HEAT SENSITIVE. FREEZE. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe Information dust. Always store away from incompatible compounds such as oxidizing agents. Section VIII. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended Engineering Controls exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Dust respirator. Lab coat. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent. Exposure LimitsNot available. Section IX. Physical and Chemical Properties Solid. (Pale yellow to yellow red crystallineSolubility Physical state @ 20°CSoluble in acetone. powder.) Not available. Specific Gravity Molecular Weight368.38Partition CoefficientNot available. Boiling PointNot available.Vapor PressureNot applicable. 186°C (366.8°F)Not available. Melting PointVapor Density Refractive IndexNot available.VolatilityNot available. Not available.Not available. Critical TemperatureOdor ViscosityNot available.TasteNot available. Section X.Stability and Reactivity Data This material is stable if stored under proper conditions. (See Section VII for instructions) Stability Conditions of InstabilityFreeze. Heat sensitive. Avoid excessive heat and light. Incompatibilities Reactive with oxidizing agents. Section XI. Toxicological Information MI5230000 RTECS Number Eye Contact. Ingestion. Inhalation. Routes of Exposure Rat LD50 (oral) 12.2gm/kg Toxicity Data Mouse LD50 (oral) >2000mg/kg Mouse LD50 (ipr) 1500mg/kg Continued on Next Page Curcumin (Synthetic) Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : TUMORIGENIC EFFECTS: Rat TDLo: Oral; 12600 mg/kg/6W continuous TOXIC EFFECTS: Tumorigenic - Neoplastic by RTECS criteria Liver - Tumors Tumorigenic - Facilitates action of known carcinogens DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS: Rat TDLo: Oral; 43 gm/kg; male 70D and70D prior to mating-1D after birth prior to mating. TOXIC EFFECTS: Effects on Newborn - Live birth index (similar to T26, except measured after birth) Effects on Newborn - Growth statistics (e.g., reduced weight gain) Rat TDLo: Oral; 10000 ppm; female multigeneration TOXIC EFFECTS: Effects on Newborn - Growth statistics (e.g., reduced weight gain) Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye Acute Toxic Effects is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Section XII.Ecological Information EcotoxicityNot available. Environmental FateNot available. Section XIII. Disposal Considerations Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a Waste Disposal combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section XIV. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. PIN Number Proper Shipping NameNot applicable. Not applicable. Packing Group (PG) DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40 CFR 720.36 (C) for those products not on the inventory list: (EPA) (i) These products are supplied solely for use in research and development by or under the supervision of a technically qualified individual as defined in 40 CFR 720.0 et sec. (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be supplied on an MSDS sheet. Not available. WHMIS Classification (Canada) EINECS Number (EEC)Not available. EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin. SECTION 16 - ADDITIONAL INFORMATION N/A |