70132-50-2

70132-50-2 structure

Name: Pimonidazole
Chemical Name: 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol
CAS Number: 70132-50-2
Molecular Formula: C₁₁H₁₈N₄O₃
Molecular Weight: 254.286
Catalog: Research Areas Others
Create Date: 2018-05-05 08:00:00
Modify Date: 2024-01-02 18:23:18
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole is used for intravenous administration followed by biopsy, it can be used for qualitative and quantitative assessment of tumor hypoxia[1].Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group[2].

Name	1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol
Synonyms	1-Piperidineethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]- Pimonidazol (±)-a-[(2-nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol UNII:46JO4D76R2 Pimonidazole [INN:BAN] Pimonidazole Pimonidazol [Spanish] 1-(2-nitro-imidazol-1-yl)-3-piperidin-1-yl-propan-2-ol 1-(2-Nitro-1H-imidazol-1-yl)-3-(1-piperidinyl)-2-propanol (±)-α-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol 1-(2-nitroimidazol-1-yl)-3-(1-piperidinyl)-2-propanol 1-(2-Nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol Pimonidazolum Ro 03-8799 Pimonidazolum [Latin]

Description	Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole is used for intravenous administration followed by biopsy, it can be used for qualitative and quantitative assessment of tumor hypoxia[1].Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7. [2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
RIDADR	NONH for all modes of transport

110-89-4

7440-44-0

13551-86-5

~66%

70132-50-2

Literature: Hoffmann-La Roche Inc. Patent: US4241060 A1, 1980 ;

Precursor 3
110-89-4 7440-44-0 13551-86-5
DownStream 0