Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HZ52
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: HZ52
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1077626-51-7

1077626-51-7 structure

1077626-51-7 structure

Name: HZ52
Chemical Name: hz52
CAS Number: 1077626-51-7
Molecular Formula: C₂₄H₂₆ClN₃O₂S
Molecular Weight: 456.000
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2017-01-08 00:30:40
Modify Date: 2024-01-03 23:04:29
HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].

Name	hz52
Synonyms	Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]- 2-{[4-(4-Biphenylylamino)-6-chloro-2-pyrimidinyl]sulfanyl}octanoic acid

Description	HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93.

Density	1.3±0.1 g/cm3
Boiling Point	625.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₆ClN₃O₂S
Molecular Weight	456.000
Flash Point	332.0±31.5 °C
Exact Mass	455.143433
PSA	100.41000
LogP	9.07
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.641

RIDADR	NONH for all modes of transport

1167989-90-3 structure

1167989-90-3

~%

1077626-51-7 structure

1077626-51-7

Literature: Koeberle, Andreas; Zettl, Heiko; Greiner, Christine; Wurglics, Mario; Schubert-Zsilavecz, Manfred; Werz, Oliver Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8068 - 8076