913827-99-3
913827-99-3 structure
- Name: CS 2100
- Chemical Name: 1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thieny l}methyl)-3-azetidinecarboxylic acid
- CAS Number: 913827-99-3
- Molecular Formula: C25H23N3O4S
- Molecular Weight: 461.53
- Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
- Create Date: 2017-09-24 03:30:21
- Modify Date: 2024-02-03 10:55:16
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CS-2100 (Compound 10b) is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID50 (infective dose) of 0.407 mg/kg for HvGR[1].
| Name | 1-({4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thieny l}methyl)-3-azetidinecarboxylic acid |
|---|---|
| Synonyms |
1-({4-[1-(3-oxo-3-phenyl-propyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-acetyl)-pyrrolidine
1-({4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid Pyrrolidine,1-((4-((1-(3-oxo-3-phenylpropyl)-1H-benzimidazol-2-yl)methyl)-1-piperazinyl)acetyl) 1-(2'-Benzoyleth-1'-yl)-2-(4''-pyrrolidinocarbonylmethylpiperazine-1''-ylmethyl)benzimidazole |
| Description | CS-2100 (Compound 10b) is a potent, selective, orally active and S1P3-sparing S1P1 agonist with an EC50 of 4.0 nM for human S1P1. CS-2100 shows in vivo immunosuppressive efficacy in rats with an ID50 (infective dose) of 0.407 mg/kg for HvGR[1]. |
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| Related Catalog | |
| Target |
EC50: 4.0 nM (human S1P1)[1] |
| References |
| Molecular Formula | C25H23N3O4S |
|---|---|
| Molecular Weight | 461.53 |
| Exact Mass | 461.14100 |
| PSA | 116.93000 |
| LogP | 5.27410 |
