139461-37-3

139461-37-3 structure

Name: Nomega-Allyl-L-arginine hydrochloride
Chemical Name: (2S)-2-amino-5-[(N'-prop-2-enylcarbamimidoyl)amino]pentanoic acid
CAS Number: 139461-37-3
Molecular Formula: C₉H₁₈N₄O₂
Molecular Weight: 214.26500
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2017-09-05 02:50:26
Modify Date: 2024-01-10 17:04:31
Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O[1][2].

Name	(2S)-2-amino-5-[(N'-prop-2-enylcarbamimidoyl)amino]pentanoic acid
Synonyms	L-Ornithine,N5-(imino(2-propenylamino)methyl) N(G)-Allylarginine NG-allyl-L-arginine Nw-allyl-L-arginine ARV

Description	Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
Target	nitric oxide synthase (nNOS)[1]
References	[1]. Zhang HQ, et, al. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by Nω-Allyl-l-Arginine. J. Am. Chem. Soc. 1997, 119, 45, 10888-10902. [2]. Hah JM, et, al. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorg Med Chem. 2000 Aug;8(8):1931-6.