Ipatasertib-NH2 dihydrochloride

Modify Date: 2024-06-21 17:55:08

Ipatasertib-NH2 dihydrochloride Structure
Ipatasertib-NH2 dihydrochloride structure
Common Name Ipatasertib-NH2 dihydrochloride
CAS Number 1001264-73-8 Molecular Weight 488.84
Density N/A Boiling Point N/A
Molecular Formula C21H28Cl3N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ipatasertib-NH2 dihydrochloride


Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

 Names

Name Ipatasertib-NH2 dihydrochloride

 Ipatasertib-NH2 dihydrochloride Biological Activity

Description Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

 Chemical & Physical Properties

Molecular Formula C21H28Cl3N5O2
Molecular Weight 488.84
Storage condition 2-8°C
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