UNII:R99EE080JS

Modify Date: 2024-01-11 17:02:52

UNII:R99EE080JS Structure
UNII:R99EE080JS structure
Common Name UNII:R99EE080JS
CAS Number 100324-80-9 Molecular Weight 280.323
Density 1.3±0.1 g/cm3 Boiling Point 511.2±56.0 °C at 760 mmHg
Molecular Formula C13H20N4O3 Melting Point N/A
MSDS N/A Flash Point 263.0±31.8 °C

 Use of UNII:R99EE080JS


(S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline[1][2].

 Names

Name (S)-Lisofylline
Synonym More Synonyms

 UNII:R99EE080JS Biological Activity

Description (S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline[1][2].
Related Catalog
In Vitro (S)-Lisofylline 在人溶血红细胞中能与己酮可可碱相互转化[2]。
In Vivo (S)-Lisofylline (50 mg/kg;静脉注射;单剂量) 在小鼠肝脏、肾脏和肺部中显示出较高的含量,但在血清中含量较低[2]。
References

[1]. Borowiecki P, et al. Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system[J]. Catalysis Science & Technology, 2022, 12(13): 4312-4324.

[2]. Wyska E, et al. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality. 2006 Aug;18(8):644-51.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 511.2±56.0 °C at 760 mmHg
Molecular Formula C13H20N4O3
Molecular Weight 280.323
Flash Point 263.0±31.8 °C
Exact Mass 280.153534
PSA 82.05000
LogP 0.34
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.621

 Synonyms

(S)-Lisofylline
UNII:R99EE080JS
Amendol
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-
1-[(5S)-5-Hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Di-O-methyl-osajetin
1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl-
1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione