SB 4
Modify Date: 2023-01-27 17:20:22
SB 4 structure
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Common Name | SB 4 | ||
|---|---|---|---|---|
| CAS Number | 100874-08-6 | Molecular Weight | 320.204 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 444.2±47.0 °C at 760 mmHg | |
| Molecular Formula | C14H10BrNOS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 222.4±29.3 °C | |
Use of SB 4BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes; increases the phosphorylation of key second messengers (SMADs-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, ID1 and ID3) in canonical BMP signaling. |
| Name | 2-[(4-Bromobenzyl)sulfanyl]-1,3-benzoxazole |
|---|---|
| Synonym | More Synonyms |
| Description | BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes; increases the phosphorylation of key second messengers (SMADs-1/5/9) and also increased expression of direct target genes (inhibitors of DNA binding, ID1 and ID3) in canonical BMP signaling. |
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| Related Catalog | |
| Target |
IC50: BMP4 signal[1] |
| In Vitro | BMP signaling agonist sb4 (0.05 μM-1 μM; 24 hours) induces phosphorylated SMAD-1/5/9 in a dose-dependent manner in PRECs cells under serum-starved conitions[1]. BMP signaling agonist sb4 (1 μM; 0-60 mins) enhances the efficacy of signaling at each concentration of rhBMP4 tested. This effect is most pronounced at low concentrations of rhBMP4, whereby sb4 increases BRE-luc expression 2-fold at 0.4 ng/ml of rhBMP4[1]. Western Blot Analysis[1] Cell Line: Primary mouse kidney epithelial cells (PRECs) Concentration: 0.05 μM-1 μM Incubation Time: 24 hours Result: Incresed p-SMAD-1/5/9 abundance in PRECs. Western Blot Analysis[1] Cell Line: BRE-Luc cells Concentration: 1 μM Incubation Time: 0min, 5 mins, 15 mins, 30 mins, 45 mins, 60 mins Result: Acted to stabilize p-SMAD-1/5/9 to enhance the transcriptional response. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 444.2±47.0 °C at 760 mmHg |
| Molecular Formula | C14H10BrNOS |
| Molecular Weight | 320.204 |
| Flash Point | 222.4±29.3 °C |
| Exact Mass | 318.966644 |
| LogP | 5.40 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.715 |
| Benzoxazole, 2-[[(4-bromophenyl)methyl]thio]- |
| 2-[(4-Bromobenzyl)sulfanyl]-1,3-benzoxazole |