Methyl salvionolate A

Modify Date: 2024-02-03 11:20:46

Methyl salvionolate A Structure
Methyl salvionolate A structure
Common Name Methyl salvionolate A
CAS Number 1015171-69-3 Molecular Weight 508.474
Density 1.5±0.1 g/cm3 Boiling Point 824.5±65.0 °C at 760 mmHg
Molecular Formula C27H24O10 Melting Point N/A
MSDS N/A Flash Point 278.2±27.8 °C

 Use of Methyl salvionolate A


Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1].

 Names

Name (2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate
Synonym More Synonyms

 Methyl salvionolate A Biological Activity

Description Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1].
Related Catalog
References

[1]. Wang Q, et al. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. J Nat Prod. 2018 Nov 26;81(11):2531-2538.  

[2]. Zhang ZF, et al. Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 824.5±65.0 °C at 760 mmHg
Molecular Formula C27H24O10
Molecular Weight 508.474
Flash Point 278.2±27.8 °C
Exact Mass 508.136932
LogP 4.65
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.747
Water Solubility Insuluble (5.6E-3 g/L) (25 ºC)

 Synonyms

(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate
Benzenepropanoic acid, α-[[(2E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, methyl ester, (αR)-
Methyl salvionolate A
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