RO 5073012
Modify Date: 2024-03-05 15:36:11
RO 5073012 structure
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Common Name | RO 5073012 | ||
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| CAS Number | 1020814-70-3 | Molecular Weight | 249.742 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H16ClN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RO 5073012A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models. |
| Name | RO 5073012 |
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| Description | A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models. |
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| References | References 1. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. 2. Revel FG, et al. Neuropsychopharmacology. 2012 Nov;37(12):2580-92. View Related Products by Target Trace Amine-associated Receptor (TAAR) |
| Molecular Formula | C13H16ClN3 |
|---|---|
| Molecular Weight | 249.742 |