Isoprocurcumenol

Modify Date: 2024-01-16 15:42:56

Isoprocurcumenol structure	Common Name	Isoprocurcumenol
	CAS Number	102130-90-5	Molecular Weight	234.334
	Density	1.1±0.1 g/cm3	Boiling Point	360.3±41.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₂O₂	Melting Point	99.5-100.5 ºC (hexane )
	MSDS	N/A	Flash Point	153.7±20.2 °C

Use of Isoprocurcumenol

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and Akt. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].

Name	iso-Procurcumenol
Synonym	More Synonyms

Description	Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and Akt. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> EGFR Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK Akt
In Vitro	Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化[3]。 Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖[3]。 Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1[ 3]。 Isoprocurcumenol 诱导细胞恢复和伤口愈合[3]。 Western Blot Analysis[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 10 μM Incubation Time: 10, 30, or 60 min Result: Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h. Cell Proliferation Assay[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM Incubation Time: 24 or 48 h Result: Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM. RT-PCR[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 1 μM Incubation Time: 1 h Result: Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.
References	[1]. Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4. [2]. Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414. [3]. Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22(22):12579.

Density	1.1±0.1 g/cm3
Boiling Point	360.3±41.0 °C at 760 mmHg
Melting Point	99.5-100.5 ºC (hexane )
Molecular Formula	C₁₅H₂₂O₂
Molecular Weight	234.334
Flash Point	153.7±20.2 °C
Exact Mass	234.161987
LogP	2.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.523
Water Solubility	Very slightly soluble (0.82 g/L) (25 ºC)