Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)-
Modify Date: 2024-01-10 09:53:17
Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)- structure
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Common Name | Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)- | ||
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| CAS Number | 10245-81-5 | Molecular Weight | 553.66 | |
| Density | 2.606g/cm3 | Boiling Point | 464.2ºC at 760 mmHg | |
| Molecular Formula | C10H4Br5NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 234.5ºC | |
Use of Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)-Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1]. |
| Name | 2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol |
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| Synonym | More Synonyms |
| Description | Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1]. |
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| Related Catalog | |
| In Vitro | Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位[1]。 PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应[1]。 PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT[1]。 PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移[1]。 PBrP (0.01-1⟩μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。 PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。 Western Blot Analysis[1] Cell Line: Mv1Lu, A549, Clone 9 and HepG2 cells Concentration: 0.01-1 μM (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5 μM (Mv1Lu, A549 and HepG2 cells) Incubation Time: 6 h (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5, 1, 2, 4, 6 h (Mv1Lu, A549 and HepG2 cells) Result: Suppressed the TGF-β-stimulated Smad2/3 phosphorylation in a dose-dependent manner in these cell lines. Prevented TGF-β induced the nuclear translocation of Smad2/3 and PBrP alone did not alter the localisation of Smad proteins. Immunofluorescence[1] Cell Line: A549 cells Concentration: 0.2 μM Incubation Time: 6 h Result: Abolished TGF-β-induced Smad2/3 nuclear translocation. Cell Migration Assay [1] Cell Line: A549 cells Concentration: 0.2 μM Incubation Time: 20 h Result: Suppressed TGF-β-stimulated cell migration and did not close the wound. |
| References |
| Density | 2.606g/cm3 |
|---|---|
| Boiling Point | 464.2ºC at 760 mmHg |
| Molecular Formula | C10H4Br5NO |
| Molecular Weight | 553.66 |
| Flash Point | 234.5ºC |
| Exact Mass | 548.62100 |
| PSA | 36.02000 |
| LogP | 6.19980 |
| Vapour Pressure | 3.07E-09mmHg at 25°C |
| Index of Refraction | 1.739 |
| HS Code | 2933990090 |
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| Precursor 9 | |
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| DownStream 0 | |
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CAS#:10245-82-6| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 2,4-dibromo-6-(3,4,5-tribromo-pyrrol-2-yl)-phenol |
| Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl) |
| pentabromopseulidin |
| 2,3,4-tribromo-5-(1'-hydroxy-2',4'-dibromophenyl)-pyrrole |
| PBQ |
| Pentabromopseudilin |