18β-Glycyrrhetyl-3-O-sulfate

Modify Date: 2024-04-02 18:28:44

18β-Glycyrrhetyl-3-O-sulfate Structure
18β-Glycyrrhetyl-3-O-sulfate structure
Common Name 18β-Glycyrrhetyl-3-O-sulfate
CAS Number 10251-38-4 Molecular Weight 550.75
Density N/A Boiling Point N/A
Molecular Formula C30H46O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 18β-Glycyrrhetyl-3-O-sulfate


18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research[1][2].

 Names

Name 18β-Glycyrrhetyl-3-O-sulfate

 18β-Glycyrrhetyl-3-O-sulfate Biological Activity

Description 18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research[1][2].
Related Catalog
References

[1]. Kan'ichiro Ishiuchi, et al. 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism. Sci Rep. 2019 Feb 7;9(1):1587.  

[2]. Kan'ichiro Ishiuchi, et al. Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker.  

 Chemical & Physical Properties

Molecular Formula C30H46O7S
Molecular Weight 550.75
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