bullatacin

Modify Date: 2024-01-19 12:28:07

bullatacin structure	Common Name	bullatacin
	CAS Number	102989-24-2	Molecular Weight	622.91600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₆₆O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of bullatacin

Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].

Name	(+)-asimicin

Description	Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
In Vitro	Asimicin 对人肿瘤细胞具有抑制作用，对 A-549 和 MCF-7 的 ED50 分别为 0.00843 和 0.852 μg/mL[2]。 Asimicin 对秀丽隐杆线虫具有显著活性，IC100 值为 0.1 µg/mL[3]。
References	[1]. Kawamata T, et al. Convergent Total Synthesis of Asimicin via Decarbonylative Radical Dimerization. Chemistry. 2018 Dec 17;24(71):18907-18912. [2]. Zhao GX, et al. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. J Med Chem. 1994 Jun 24;37(13):1971-6. [3]. Ligang Zhou, et al. Secondary Metabolites with Antinematodal Activity from Higher Plants. Studies in Natural Products Chemistry. Volume 37, 2012, Pages 67-114. [4]. E. David Morgan and Ian D. Wilson. Insect Hormones and Insect Chemical Ecology. Comprehensive Natural Products Chemistry. Volume 8, 1999, Pages 263-375.

Molecular Formula	C₃₇H₆₆O₇
Molecular Weight	622.91600
Exact Mass	622.48100
PSA	105.45000
LogP	7.85790
Vapour Pressure	1.19E-25mmHg at 25°C

Precursor 10
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