Cas9-IN-2

Modify Date: 2024-01-08 11:23:29

Cas9-IN-2 Structure
Cas9-IN-2 structure
Common Name Cas9-IN-2
CAS Number 1030133-34-6 Molecular Weight 477.60
Density N/A Boiling Point N/A
Molecular Formula C21H27N5O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cas9-IN-2


Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

 Names

Name Cas9-IN-2

 Cas9-IN-2 Biological Activity

Description Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].
Related Catalog
In Vitro Cas9-IN-1 (compound 2) (200 and 500 μM; overnight) helps the E. coli selection strain to survive SpyCas9-induced killing[1].
References

[1]. Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65(4):3266-3305.

 Chemical & Physical Properties

Molecular Formula C21H27N5O4S2
Molecular Weight 477.60