![]() E1231 structure
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Common Name | E1231 | ||
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CAS Number | 1031195-19-3 | Molecular Weight | 363.410 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 605.8±55.0 °C at 760 mmHg | |
Molecular Formula | C21H21N3O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 320.2±31.5 °C |
Use of E1231E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models. |
Name | 1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone |
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Synonym | More Synonyms |
Description | E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models. |
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References | References 1. Feng T, et al. Atherosclerosis. 2018 Jul;274:172-181. View Related Products by Target Sirtuin |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 605.8±55.0 °C at 760 mmHg |
Molecular Formula | C21H21N3O3 |
Molecular Weight | 363.410 |
Flash Point | 320.2±31.5 °C |
Exact Mass | 363.158295 |
LogP | 1.30 |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.626 |
MFCD10627184 |
1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone |
Ethanone, 1-[4-[[2-(5-methyl-2-furanyl)-4-quinolinyl]carbonyl]-1-piperazinyl]- |