ABC 1183
Modify Date: 2024-01-16 10:14:47
ABC 1183 structure
|
Common Name | ABC 1183 | ||
|---|---|---|---|---|
| CAS Number | 1042735-18-1 | Molecular Weight | 334.397 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABC 1183ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression; suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo. |
| Name | ABC 1183 |
|---|
| Description | ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression; suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo. |
|---|---|
| References | References 1. Schrecengost RS, et al. J Pharmacol Exp Ther. 2018 Feb 6. pii: jpet.117.245738. View Related Products by Target GSK-3 |
| Molecular Formula | C18H14N4OS |
|---|---|
| Molecular Weight | 334.397 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ABC 1183
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: ABC 1183
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: ABC 1183
- Price: $950.0/100mg $220.0/10ml
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link: