GGTI 2418 sodium
Modify Date: 2024-07-21 17:37:50
GGTI 2418 sodium structure
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Common Name | GGTI 2418 sodium | ||
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| CAS Number | 1044590-78-4 | Molecular Weight | 463.514 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30N5NaO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GGTI 2418 sodiumGGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors. |
| Name | GGTI 2418 sodium |
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| Description | GGTI 2418 sodium (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase; demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM; suppresses the growth of human breast tumors in nude mouse xenografts; increases p27(Kip1) and induces significant regression of breast tumors. |
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| References | References 1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558. 2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63. View Related Products by Target Other Targets |
| Molecular Formula | C23H30N5NaO4 |
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| Molecular Weight | 463.514 |