NS13001
Modify Date: 2024-10-05 09:58:06
NS13001 structure
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Common Name | NS13001 | ||
|---|---|---|---|---|
| CAS Number | 1062592-30-6 | Molecular Weight | 339.787 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14ClN7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NS13001A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice. |
| Name | NS13001 |
|---|
| Description | A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice. |
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| References | References 1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53. 2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. View Related Products by Target Potassium Channel |
| Molecular Formula | C16H14ClN7 |
|---|---|
| Molecular Weight | 339.787 |