NS13001

Modify Date: 2023-01-14 07:51:30

NS13001 Structure
NS13001 structure
Common Name NS13001
CAS Number 1062592-30-6 Molecular Weight 339.787
Density N/A Boiling Point N/A
Molecular Formula C16H14ClN7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NS13001


A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.

 Names

Name NS13001

 NS13001 Biological Activity

Description A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.
References References 1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53. 2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. View Related Products by Target Potassium Channel

 Chemical & Physical Properties

Molecular Formula C16H14ClN7
Molecular Weight 339.787
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: NS13001
  • Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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