CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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RV0480000
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CHEMICAL NAME :
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Paraffin waxes and hydrocarbon waxes, chlorinated (C12, 60% chlorine)
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CAS REGISTRY NUMBER :
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108171-26-2
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LAST UPDATED :
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199510
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>13600 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>27200 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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120 gm/kg/16D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
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REFERENCE :
-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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325 gm/kg/13W-I
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
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REFERENCE :
-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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30 gm/kg/16D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
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REFERENCE :
-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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32 gm/kg/13W-I
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TOXIC EFFECTS :
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Liver - changes in liver weight
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REFERENCE :
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FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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227 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-308,1986
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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182 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-308,1986
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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227 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Endocrine - thyroid tumors
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REFERENCE :
-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-308,1986
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TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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227 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
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REFERENCE :
-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-308,1986
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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917 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Liver - tumors Skin and Appendages - tumors
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REFERENCE :
-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-308,1986
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
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DOSE/DURATION :
-
228 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia
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REFERENCE :
-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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91250 mg/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Liver - tumors
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REFERENCE :
-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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183 gm/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors
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REFERENCE :
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FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,454,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,55,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,55,1990
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