Filipin complex

Modify Date: 2024-01-02 13:26:10

Filipin complex Structure
Filipin complex structure
Common Name Filipin complex
CAS Number 11078-21-0 Molecular Weight 654.82800
Density 1.161 g/cm3 Boiling Point 913.9ºC at 760 mmHg
Molecular Formula C35H58O11(forFilipinIII) Melting Point N/A
MSDS Chinese USA Flash Point 279.3ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Filipin complex


Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].

 Names

Name Filipin complex from Streptomyces filipinensis
Synonym More Synonyms

 Filipin complex Biological Activity

Description Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].
Related Catalog
References

[1]. Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9.

[2]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

 Chemical & Physical Properties

Density 1.161 g/cm3
Boiling Point 913.9ºC at 760 mmHg
Molecular Formula C35H58O11(forFilipinIII)
Molecular Weight 654.82800
Flash Point 279.3ºC
Exact Mass 654.39800
PSA 208.37000
LogP 1.88800
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK4400000
CHEMICAL NAME :
Filipin
CAS REGISTRY NUMBER :
11078-21-0
LAST UPDATED :
198211

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,215,1980

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xn: Harmful;Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

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 Synonyms

(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,1 0,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethylo xacyclooctacosa-17,19,21,23,25-pentaen-2-one