LB-205

Modify Date: 2024-08-30 10:47:57

LB-205 Structure
LB-205 structure
Common Name LB-205
CAS Number 1113025-86-7 Molecular Weight 343.445
Density N/A Boiling Point N/A
Molecular Formula C18H21N3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LB-205


A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.

 Names

Name LB-205

 LB-205 Biological Activity

Description A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.
References References 1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. 2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. View Related Products by Target HDAC

 Chemical & Physical Properties

Molecular Formula C18H21N3O2S
Molecular Weight 343.445
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