Iclaprim-d6

Modify Date: 2024-01-10 22:48:58

Iclaprim-d6 structure	Common Name	Iclaprim-d6
	CAS Number	1130072-57-9	Molecular Weight	360.44000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆D₆N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Iclaprim-d6

Iclaprim-d6 (AR-100-d6) is the deuterium labeled Iclaprim. Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.

Name	5-[[2-cyclopropyl-7,8-bis(trideuteriomethoxy)-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine
Synonym	More Synonyms

Description	Iclaprim-d6 (AR-100-d6) is the deuterium labeled Iclaprim. Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schneider P, et al. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4217-21. [3]. Kohlhoff SA, et al. Iclaprim. Expert Opin Investig Drugs. 2007 Sep;16(9):1441-8.

Molecular Formula	C₁₉H₁₆D₆N₄O₃
Molecular Weight	360.44000
Exact Mass	360.20700
PSA	106.97000
LogP	2.29340

Iclaprim-d6

AR 100-d6

Iclaprim-d6

Use of Iclaprim-d6

Names

Iclaprim-d6 Biological Activity

Chemical & Physical Properties

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