Apixaban-d3

Modify Date: 2024-01-03 10:30:53

Apixaban-d3 Structure
Apixaban-d3 structure
Common Name Apixaban-d3
CAS Number 1131996-12-7 Molecular Weight 462.52
Density N/A Boiling Point N/A
Molecular Formula C25H22D3N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Apixaban-d3


Apixaban-d3 (BMS-562247-01-d3)is the deuterium labeledApixaban(HY-50667)[1]. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[3].

 Names

Name 7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1-[4-(trideuteriomethoxy)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
Synonym More Synonyms

 Apixaban-d3 Biological Activity

Description Apixaban-d3 (BMS-562247-01-d3)is the deuterium labeledApixaban(HY-50667)[1]. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[3].
Related Catalog
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

 Chemical & Physical Properties

Molecular Formula C25H22D3N5O4
Molecular Weight 462.52
Exact Mass 462.20900
PSA 111.75000
LogP 3.71380

 Synonyms

Apixaban-d3