PVZB-1194

Modify Date: 2024-02-03 11:25:54

PVZB-1194 Structure
PVZB-1194 structure
Common Name PVZB-1194
CAS Number 1141768-04-8 Molecular Weight 319.275
Density 1.4±0.1 g/cm3 Boiling Point 417.0±55.0 °C at 760 mmHg
Molecular Formula C13H9F4NO2S Melting Point N/A
MSDS N/A Flash Point 206.0±31.5 °C

 Use of PVZB-1194


PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.

 Names

Name 3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
Synonym More Synonyms

 PVZB-1194 Biological Activity

Description PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.
References References 1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. 2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36. View Related Products by Target Kinesin

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 417.0±55.0 °C at 760 mmHg
Molecular Formula C13H9F4NO2S
Molecular Weight 319.275
Flash Point 206.0±31.5 °C
Exact Mass 319.029022
LogP 3.26
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.536

 Synonyms

3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
[1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)-
3'-Fluoro-4'-(Trifluoromethyl)biphenyl-4-Sulfonamide
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