Tripolin A

Modify Date: 2024-01-09 13:10:22

Tripolin A Structure
Tripolin A structure
Common Name Tripolin A
CAS Number 1148118-92-6 Molecular Weight 253.25274
Density N/A Boiling Point N/A
Molecular Formula C15H11NO3 Melting Point 265℃ (decomposition)
MSDS N/A Flash Point N/A

 Use of Tripolin A


Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].

 Names

Name Tripolin A

 Tripolin A Biological Activity

Description Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].
Related Catalog
Target

IC50: 1.5 μM (Aurora A), 7 μM (Aurora A)[1].

In Vitro Tripolin A induces mitotic spindle defects and spindle pole abnormalities[1].
References

[1]. Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.

 Chemical & Physical Properties

Melting Point 265℃ (decomposition)
Molecular Formula C15H11NO3
Molecular Weight 253.25274
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