arg-pro-pro-gly-phe-ser-pro-leu acetate salt

Modify Date: 2024-02-29 08:13:53

arg-pro-pro-gly-phe-ser-pro-leu acetate salt Structure
arg-pro-pro-gly-phe-ser-pro-leu acetate salt structure
Common Name arg-pro-pro-gly-phe-ser-pro-leu acetate salt
CAS Number 115035-45-5 Molecular Weight 930.06
Density N/A Boiling Point N/A
Molecular Formula C43H67N11O12 Melting Point N/A
MSDS USA Flash Point N/A

 Use of arg-pro-pro-gly-phe-ser-pro-leu acetate salt


Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research[1].

 Names

Name arg-pro-pro-gly-phe-ser-pro-leu acetate salt
Synonym More Synonyms

  Biological Activity

Description Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research[1].
Related Catalog
Target

IC50: B1R[1]

References

[1]. Ji-Zhe Jin, et al. Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction. Acta Pharmacol Sin. 2020 Dec;41(12):1597-1608.  

 Chemical & Physical Properties

Molecular Formula C43H67N11O12
Molecular Weight 930.06
Exact Mass 929.49700
PSA 360.08000
LogP 0.84570

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles3

More Articles
Upregulation of B1 receptor mediating des-Arg9-BK-induced rat paw oedema by systemic treatment with bacterial endotoxin.

Br. J. Pharmacol. 117 , 793-798, (1996)

1. The effect of pretreatment with bacterial endotoxin (LPS, 10 micrograms, i.v., 24 h) on the bradykinin B1 and B2 receptor-induced oedema in the rat paw, and the interaction of B1-mediated responses...

Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade.

Hypertension 48 , 942-949, (2006)

It has been suggested that the effects of angiotensin II type 1 receptor (AT1R) blockers are in part because of angiotensin II type 2 receptor (AT2R) signaling. Interactions between the AT2R and kinin...

The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice.

Neuropharmacology 54 , 597-604, (2008)

The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC). In the present study, we examine the contribut...

 Synonyms

arg-pro-pro-gly-phe-ser-pro-leu acoh 3h2o