Endothelin-3 (human, mouse, rabbit, rat) acetate salt

Modify Date: 2024-01-05 19:54:49

Endothelin-3 (human, mouse, rabbit, rat) acetate salt structure	Common Name	Endothelin-3 (human, mouse, rabbit, rat) acetate salt
	CAS Number	117399-93-6	Molecular Weight	2643.04000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂₁H₁₆₈N₂₆O₃₃S₄	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Endothelin-3 (human, mouse, rabbit, rat) acetate salt

Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Name	Endothelin 3 human, rat
Synonym	More Synonyms

Description	Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	ET-RA, ET-RB[1]
In Vitro	The endothelins (ETs) are a family of 21-amino-acid vasoconstrictor peptides comprising three distinct isoforms: ET-1, ET2 and Endothelin-3. Endothelin-3 is detected in plasma, heart, brain and vascular smooth muscle cells (VSMCs). The surface enzymes of VSMCs break down big Endothelin-3 to the corresponding mature peptide, Endothelin-3. Endothelin-3 down-regulate endothelin ETA receptor expression in coronary artery VSMCs without affecting receptor density or functional ETA receptor responses. By contrast, high concentrations of Endothelin-3 (100 nM) increase the expression of ETB receptors but abolish the vasoconstrictor response of the receptors, possibly due to the desensitizing effect of Endothelin-3[1]. Endothelin-3 stimulates ENCC adhesion to various ECM components. Endothelin-3 induces rapid changes in ENCC shape and protrusion dynamics favouring sustained growth and stabilization of lamellipodia, a process coincident with the increase in the number of focal adhesions and activated β1-integrins[2].
In Vivo	Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3].
References	[1]. Skovsted GF, et al. Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries. Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):297-305. [2]. Gazquez E, et al. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci Rep. 2016 Dec 1;6:37877. doi: 10.1038/srep37877. [3]. Sato A, et al. Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. Inflamm Res. 2013 Apr;62(4):417-24.

Molecular Formula	C₁₂₁H₁₆₈N₂₆O₃₃S₄
Molecular Weight	2643.04000
Exact Mass	2641.11000
PSA	1056.08000
LogP	6.33930
Appearance of Characters	powder \| white
Storage condition	−20°C

Safety Phrases	S22
RIDADR	NONH for all modes of transport
WGK Germany	3

Involvement of endothelins in deoxycorticosterone acetate-salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus.

Exp. Physiol. 100 , 617-27, (2015)

What is the central question of this study? Does ex vivo administration of endothelin-1 and endothelin-3 regulate noradrenergic transmission in the posterior hypothalamus of deoxycorticosterone acetat...

Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors.

Nat. Commun. 5 , 5807, (2014)

Direct reprogramming provides a fundamentally new approach for the generation of patient-specific cells. Here, by screening a pool of candidate transcription factors, we identify that a combination of...

Analysis of immunostaining and western blotting of endothelin 1 and its receptors in mitral stenosis.

Rev. Bras. Cir. Cardiovasc. 30 , 211-8, (2015)

Rheumatic Fever represents a serious public health problem in developing countries, with thousands of new cases each year. It is an autoimmune disease, which occurs in response to infection by strepto...

ET-3

MFCD00076378

Endothelin 3 human,rat

Endothelin-3, human

Endothelin-3, human, mouse, rabbit, rat