DSP-1053

Modify Date: 2024-04-08 19:33:32

DSP-1053 Structure
DSP-1053 structure
Common Name DSP-1053
CAS Number 1176326-78-5 Molecular Weight 660.62
Density N/A Boiling Point N/A
Molecular Formula C32H38BrNO7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DSP-1053


DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo. Depression Phase 1 Discontinued

 Names

Name DSP-1053

 DSP-1053 Biological Activity

Description DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo. Depression Phase 1 Discontinued
References References 1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627. 2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142. View Related Products by Target 5-HT Receptor Depression

 Chemical & Physical Properties

Molecular Formula C32H38BrNO7S
Molecular Weight 660.62
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