XX-650-23
Modify Date: 2024-04-07 13:25:29
XX-650-23 structure
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Common Name | XX-650-23 | ||
|---|---|---|---|---|
| CAS Number | 117739-40-9 | Molecular Weight | 288.306 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XX-650-23XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals. |
| Name | XX-650-23 |
|---|
| Description | XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals. |
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| References | References 1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311. 2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97. View Related Products by Target CREB/CBP |
| Molecular Formula | C18H12N2O2 |
|---|---|
| Molecular Weight | 288.306 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: XX-650-23
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: XX-650-23
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: XX-650-23
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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