AG-126

Modify Date: 2024-01-03 11:42:22

AG-126 Structure
AG-126 structure
Common Name AG-126
CAS Number 118409-62-4 Molecular Weight 215.165
Density 1.5±0.1 g/cm3 Boiling Point 381.9±42.0 °C at 760 mmHg
Molecular Formula C10H5N3O3 Melting Point 184 °C
MSDS N/A Flash Point 184.8±27.9 °C

 Use of AG-126


AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).

 Names

Name 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile
Synonym More Synonyms

 AG-126 Biological Activity

Description AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).
Related Catalog
Target

ERK2

References

[1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 381.9±42.0 °C at 760 mmHg
Melting Point 184 °C
Molecular Formula C10H5N3O3
Molecular Weight 215.165
Flash Point 184.8±27.9 °C
Exact Mass 215.033096
PSA 113.63000
LogP 1.66
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.689
Storage condition −20°C

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases 23/24/25
Safety Phrases 26-36-45
WGK Germany 3

 Synonyms

(3-hydroxy-4-nitrobenzylidene)propanedinitrile
Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]-
Tyrphostin AG 126
Tyrphostin AG127
AG-126
(3-Hydroxy-4-nitrobenzylidene)malononitrile
AG 127
AG126
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