Verapamil-d6 hydrochloride

Modify Date: 2024-01-24 17:58:23

Verapamil-d6 hydrochloride structure	Common Name	Verapamil-d6 hydrochloride
	CAS Number	1185032-80-7	Molecular Weight	497.10
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₃D₆ClN₂O₄	Melting Point	142°C dec.
	MSDS	N/A	Flash Point	N/A

Use of Verapamil-d6 hydrochloride

Verapamil-d6 (CP-16533-1-d6) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

Name	VERAPAMIL-D6, HYDROCHLORIDE

Description	Verapamil-d6 (CP-16533-1-d6) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S. [2]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567. [3]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746. [4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

References

[1]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.

[2]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.

[3]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746.

[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Melting Point	142°C dec.
Molecular Formula	C₂₇H₃₃D₆ClN₂O₄
Molecular Weight	497.10
Storage condition	Refrigerator

Verapamil-d6 hydrochloride

Use of Verapamil-d6 hydrochloride

Names

Verapamil-d6 hydrochloride Biological Activity

Chemical & Physical Properties