Amlodipine-d4

Modify Date: 2024-01-10 21:43:39

Amlodipine-d4 structure	Common Name	Amlodipine-d4
	CAS Number	1185246-14-3	Molecular Weight	412.90
	Density	1.2±0.1 g/cm3	Boiling Point	527.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₁D₄ClN₂O₅	Melting Point	131-133°C
	MSDS	N/A	Flash Point	272.6±30.1 °C

Use of Amlodipine-d4

Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

Name	3-Ethyl 5-methyl 2-({[2-amino(2H4)ethyl]oxy}methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate
Synonym	More Synonyms

Description	Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].
Related Catalog	Research Areas >> Cancer
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [2]. Kishen G. Bulsara, et al. Amlodipine. [3]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [4]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [5]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.

Description

Related Catalog

Research Areas >> Cancer

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.

[2]. Kishen G. Bulsara, et al. Amlodipine.

[3]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.

[4]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.

[5]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.

Density	1.2±0.1 g/cm3
Boiling Point	527.2±50.0 °C at 760 mmHg
Melting Point	131-133°C
Molecular Formula	C₂₀H₂₁D₄ClN₂O₅
Molecular Weight	412.90
Flash Point	272.6±30.1 °C
Exact Mass	412.170319
LogP	4.16
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.546
Storage condition	-20C

Hazard Codes	Xn

3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl-1,1,2,2-d4)oxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

3-Ethyl 5-methyl 2-({[2-amino(2H4)ethyl]oxy}methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate

Shanghai Nianxing Industrial Co., Ltd
China
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Amlodipine-d4

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