a-Homonojirimycin

Modify Date: 2024-01-05 10:45:51

a-Homonojirimycin Structure
a-Homonojirimycin structure
 Common Name a-Homonojirimycin
CAS Number 119557-99-2 Molecular Weight 193.198
Density 1.5±0.1 g/cm3 Boiling Point 432.0±45.0 °C at 760 mmHg
Molecular Formula C7H15NO5 Melting Point 207ºC
MSDS USA Flash Point 224.7±19.3 °C

 Use of a-Homonojirimycin


α-Homonojirimycin is a potent α-glucosidase inhibitor[1].

 Names

Name (2R,3S,5R,6R)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol
Synonym More Synonyms

 a-Homonojirimycin Biological Activity

Description α-Homonojirimycin is a potent α-glucosidase inhibitor[1].
Related Catalog
References

[1]. Geoffrey C. et al. α-Homonojirimycin [2,6-dideoxy-2,6-imino-d-glycero-l-gulo-heptitol] from omphalea diandra L.: isolation and glucosidase inhibtion. 1988, 29(49), 6483-6485.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 432.0±45.0 °C at 760 mmHg
Melting Point 207ºC
Molecular Formula C7H15NO5
Molecular Weight 193.198
Flash Point 224.7±19.3 °C
Exact Mass 193.095016
PSA 113.18000
LogP -2.62
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.583
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles5

More Articles
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

Bioorg. Chem. 16 , 7330-7336, (2008)

An amyio-1, 6-glucosidase inhibitor enhanced inhibition of hepatic glucose production in combination with glycogen phosphorylase inhibitor. The inhibitory activity of 1-deoxynojirimycin ( 1) toward hu...

Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae).

Carbohydr. Res. 323(1-4) , 73-80, (2000)

2,6-Dideoxy-7-O-(beta-D-glucopyranosyl) 2,6-imino-D-glycero-L-gulo- heptitol (7-O-beta-D-glucopyranosyl-alpha-homonojirimycin, 1) was isolated from the 50% methanol extract of the whole plant of Lobel...

Eight stereoisomers of homonojirimycin from D-mannose.

Org. Lett. 14(8) , 2050-3, (2012)

Although there are 32 6-azidoheptitols, there are only 16 homonojirimycin (HNJ) stereoisomers. Two epimeric azidoalditols derived from d-mannose allow the synthesis in water of eight stereoisomers of ...

 Synonyms

Hnj cpd
3,4,5-Piperidinetriol, 2,6-bis(hydroxymethyl)-, (2α,3α,4β,5α,6β)-
(2r,3r,5s,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol
(2R,3S,4R,5R,6R)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol
MFCD06797112
Homonojirimycin
(2R,3R,4R,5S,6R)-2,6-Bis(hydroxymethyl)piperidine-3,4,5-triol
2,6-Dideoxy-2,6-imino-D-glycero-L-gulo-heptitol
a-Homonojirimycin
α-Homonojirimycin
(2R,3R,4R,5S,6R)-2,6-Bis(hydroxymethyl)-3,4,5-piperidinetriol
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