Sodium 3-methyl-2-oxobutanoate-13C4,d3

Modify Date: 2024-04-03 12:52:08

Sodium 3-methyl-2-oxobutanoate-13C4,d3 structure	Common Name	Sodium 3-methyl-2-oxobutanoate-13C4,d3
	CAS Number	1215605-14-3	Molecular Weight	145.09
	Density	N/A	Boiling Point	N/A
	Molecular Formula	₁₃CH₃₁₃CH(CD₃)₁₃CO₁₃CO₂Na	Melting Point	227-230 °C (lit.) (lit.)
	MSDS	N/A	Flash Point	N/A

Use of Sodium 3-methyl-2-oxobutanoate-13C4,d3

Sodium 3-methyl-2-oxobutanoate-13C4,d3 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate[1]. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[2][3][4].

Name	2-Keto-3-(methyl-d3)-butyric acid-1,2,3,4-13C4 sodium salt
Synonym	More Synonyms

Description	Sodium 3-methyl-2-oxobutanoate-13C4,d3 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate[1]. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[2][3][4].
Related Catalog	Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93. [3]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr103(4):597-605. [4]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9894(1):68-73.

Melting Point	227-230 °C (lit.) (lit.)
Molecular Formula	₁₃CH₃₁₃CH(CD₃)₁₃CO₁₃CO₂Na
Molecular Weight	145.09
Appearance of Characters	solid

MFCD05664338