FSC 231
Modify Date: 2024-01-11 17:27:01
FSC 231 structure
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Common Name | FSC 231 | ||
|---|---|---|---|---|
| CAS Number | 1215849-96-9 | Molecular Weight | 313.136 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H10Cl2N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FSC 231FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM; inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons; blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons. |
| Name | (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate |
|---|---|
| Synonym | More Synonyms |
| Description | FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM; inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons; blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons. |
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| References | References 1. Thorsen TS, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. 2. Qiu CY, et al. J Neuroinflammation. 2012 May 29;9:108. 3. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H10Cl2N2O3 |
| Molecular Weight | 313.136 |
| Exact Mass | 312.006836 |
| LogP | 3.26 |
| Index of Refraction | 1.594 |
| (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate |
| Ethyl [(2E)-2-cyano-3-(3,4-dichlorophenyl)-2-propenoyl]carbamate |
| Carbamic acid, N-[(2E)-2-cyano-3-(3,4-dichlorophenyl)-1-oxo-2-propen-1-yl]-, ethyl ester |